Subtilisin
From Proteopedia
Subtilisin is a serine protease. It is widely used commercially in detergents. A 77 amino acid propeptide is cleaved from the N-terminus of pro-Sub to create the mature active enzyme. The images at the left and at the right correspond to one representative Subtilisin, i.e. the crystal structure of native mature subtilisin from Thermococcus kodakarensis (2z2x).
Contents |
3D Structures of Subtilisin
Native mature subtilisin
2z2x – TkSub - Thermococcus kodakarensis
1sca, 1scb, 1sbc – BsSub - Bacillus subtilis (Subtilisin Carlsberg)
1gns, 1sup, 1st2, 1st1, 1s01, 1sbt, 2sbt – BaSub - Bacillus amyloliquefaciens
1iav, 1gci, 1jea, 1st3 – BlSub - Bacillus lentus (Subtilisin Savinase)
1ea7, 3d43, 2ixt – spehricase – Sub from Bacillus sphaericus
Mutant mature subtilisin
3f49, 3co0, 2zrq – TkSubb (mutant)
1gnv, 1dui, 1sue, 1a2q, 1aqn, 1sua, 1au9, 1ak9, 1yja, 1yjb, 1yjc, 1sbh, 1sbi, 1sub, 1suc, 1sud, 1s02 – BaSub (mutant)
1ndu, 1q5p, 1c9j, 1c9m, 1c9n – BlSub (mutant)
Native unautoprocessed subtilisin (pro-Sub)
Mutant unautoprocessed subtilisin
Mature subtilisin complexed with its propeptide
3cnq – BaSub
1spb – BaSub (mutant)
3a3n, 3a3o, 3a3p, 2z56, 2z57, 2z58, 2z2y, 2z30 – TkSub
1scj – BsSub
Subtilisin complexed with polypeptide inhibitor
1y1k, 1y33, 1y34, 1y3b, 1y3c, 1y3d, 1y3f, 1y48, 1y4a, 1y4d, 1tm3, 1tm4,
1tm1, 1lw6 – BaSub+ chymotripsin inhibitor 2
3sic, 5sic, 2sic – BaSub+Streptomyces inhibitor SSI
1yu6 – BsSub+ovomucoid
1v5i – BaSubb+POIA1 peptide
1tk2, 1ndq – BlSub+gramicidin S
1r0r – BsSub+ovomucoid
1oyv – BsSub+tomato inhibitor II
1sbn, 1sib, 2sec, 1sni, 1sce – BsSub+Elgin C
1mee - BpSub+Elgin C – Bacillus pumilus
Subtilisin complexed with inhibitor
3bgo – BaSub+azide
1c3l – BsSub+Xe
1be8 – BsSub+cinnamoyl
1be6 - BsSub+cinnamoyl+acetonitrile
1bfk, 1scd – BsSub+acetonitrile
1bfu, 1af4 – BsSub+dioxane
1av7, 1avt, 3vsb, 1vsb – BsSub+boronic acid derivatives
1scn – BsSub+carbamate derivative
1bh6 – Sub DY+benzyloxycarbonyl-ala-pro-phe-chloromethyl ketone – Bacillus licheniformis
