Talin

From Proteopedia

Template:STRUCTURE 2x0c

Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 vinculin binding sites VBS1-VBS3.

Talin subdomains

2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse 2kma – mTal F0F1 – NMR 2kc1 - mTal F0 – NMR 2kc2 - mTal F1 – NMR 2hrj - cTal F2 – NMR 1mix – cTal F2F3 2kgx – mTal F3+mTal fragment – NMR

Integrin binding sites

2jsw, 2qdq – mTal IBS – NMR 3g9w – mTal F2F3+integrin tail 1miz, 1mk7, 1mk9 - hTal+integrin tail 2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR 3fyq – Tal rod IBS2 – Drosophila melanogaster

Vinculin binding sites

2kvp, 2b0h – mTal VBS3 – NMR 1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken 1u6h - cTal VBS2+ vinculin head 1t01 - cTal VBS1+ vinculin head 1syq - hTal VBS1+ vinculin head – human 1rkc - hTal VBS3+ vinculin head 1u89 - mTal VBS2 – NMR

PIP kinase binding sites

1y19 - mTal F2F3+ PIP kinase C-terminal 2g35 - mTal F3+PIP kinase peptide – NMR

Layilin binding sites

2k00 - cTal F3+layilin fragment – NMR