Ribosomal protein L3

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Crystal Structure of Ribosomal protein L3 from Thermus thermophilus (2xg0, chain E)

Ribosomal protein L3 (RPL3 ) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It binds to 23S RRNA near the 3'-end where it nucleates the assembly of the large subunit. In the archaea like in Haloarcula marismortui the L3 is called L3P (RPL3P). The images at the left and at the right correspond to one representative RPL3, i.e. the crystal structure of Ribosomal protein L3 from Thermus thermophilus (2xg0, chain E).

1 3D Structures of Ribosomal protein L3

3D Structures of Ribosomal protein L3

L3 in 50S subunit+RNA

2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL3 in 50S subunit+RNA fragments – Thermus thermophilus
2x9s, 2x9u, 3kni, 3knk, 3knm, 3kno, 2wrj, 2wrl, 2wro, 2wrr, 3hux, 3huz, 2wh2, 2wh4, 2wdi, 2wdj, 2wdl, 2wdn, 1vsp, 2v47, 2v49, 1vsa, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 3mrz, 3ms1, 3i8f, 3i8i, 3i9c, 3i9e, 3f1f, 3f1h, 3d5b, 3d5d, 2b66, 2b9n, 2b9p, 1giy - TtRPL3 in 50S subunit+5S RRNA+23S RRNA
3fin - TtRPL3 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
2wwq – EcRPL3 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli
3i1n, 3i1p, 3i1r, 3i1t, 3i20, 3i22, 3e1b, 3e1d, 3df2, 3df4, 2vhn, 2qov, 2qox, 2i2t, 2i2v, 1vs6, 1vs8, 2aw4, 2awb, 3ofd, 3og0 - EcRPL3 in 50S subunit+5S RRNA+23S RRNA
3fik, 2gya, 2gyc, 3bbx, 1p85, 1p86 - EcRPL3 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
3kcr - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase
2rdo - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM
3bbo - RPL3 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach
3iy9 – RPL3 in 50S subunit – Leishmania taretolae
2zjq, 2zjr - DrRPL3 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans
1kqs, 1qvg - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui
1jj2, 1ffk, 3cc2, 2qa4, 1s72 - HmRPL3P in 50S subunit+5S RRNA+23S RRNA
3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL3P in 50S subunit+5S RRNA+23S RRNA (mutant)
1vq4, 1vq5, 1vq7, 1vql, 1vqm, 1vqp - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+transition state analog
1vq6, 1vqk, 1vqn - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin
1vqo - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+ CCPMN
1yhq, 1yi2, 1yij, 1yjn, 1yjw - HmRPL3P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic
1yj9 - HmRPL3P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA
1qvf - HmRPL3P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix
1q86 - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin

L3 in 50S subunit + antibiotics

3cxc – RPL3 in 50S subunit+5S RRNA+23S RRNA +oxazolidinone inhibitor – Halobacterium marismortui
3dll - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+oxazolidinone inhibitor
2zjp - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+nosiheptide
3cf5 - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiostrepton
1xbp - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiamulin
1sm1 - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+quinupristin+dalfopristin
1nwx - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+ABT-773
1nwy - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+azithromycin
2ogm, 2ogn, 2ogo - DrRPL3+23S RRNA+pleuromutilin derivative
3oh5, 3oh7 – TtRPL3 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol
3ohj, 3ohk – TtRPL3 in 50S subunit+5S RRNA+23S RRNA+erythromycin
3ohz, 3oi1 – TtRPL3 in 50S subunit+5S RRNA+23S RRNA+azithromycin
3oi3, 3oi5 – TtRPL3 in 50S subunit+5S RRNA+23S RRNA+telithromycin
2qam, 2qao, 2qoz, 2qp1 - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+neomycin
2qba, 2qbc - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+gentamicin
3ofc – EcRPL3 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol
3ofz – EcRPL3 in 50S subunit+5S RRNA+23S RRNA+clindamycin
3ofq, 3ofr – EcRPL3 in 50S subunit+5S RRNA+23S RRNA+erythromycin
1vt2, 3orb – EcRPL3 in 50S subunit+5S RRNA+23S RRNA+CEM-101
1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw, 3cc4, 3cd6, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji- HmRPL3P in 50S subunit+5S RRNA+23S RRNA+antibiotic
1m90, 3cma, 3cme, 1vq8, 1vq9 - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin

L3 in 60S subunit

3jyw - RPL3 in 60S subunit – Thermomyces lanuginosus – Cryo-EM
2ftc - RPL3 in 60S subunit+16S RRNA - bovine
1s1i - yRPL3 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast

L3 in large + small ribosomal subunit

1ml5 - EcRPL3 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM
2zkr - RPL3 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM - dog

L3 in 50S subunit + ribosome releasing factor (RRF)

2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+RRF

L3 in 50S subunit + various proteins

2vhm - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix
2j28 - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM
1vor, 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc
1nkw - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc
1w2b - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal