2hr9
From Proteopedia
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Solution structure of human translationally controlled tumor protein
Overview
Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone, dynamics of human TCTP, and identified the calcium-binding site of human, TCTP using multi-dimensional NMR spectroscopy. The overall structure of, human TCTP has a rather rigid well-folded core and a very flexible long, loop connected by a short two-strand beta-sheet, which shows a conserved, fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8), and strand beta9 and the N-terminal region of strand beta8 may form a, calcium-binding site in the human TCTP structure, which is largely, conserved in the sequence alignment of TCTPs. The K(d) value for the, calcium binding is 0.022-0.025M indicating a very weak calcium-binding, site.
About this Structure
2HR9 is a Single protein structure of sequence from Homo sapiens. This structure superseeds the now removed PDB entry 1Y41. Full crystallographic information is available from OCA.
Reference
Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR., Feng Y, Liu D, Yao H, Wang J, Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616
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