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1uzg
From Proteopedia
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CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN
Overview
Dengue virus is an emerging global health threat. The major envelope, glycoprotein, E, mediates viral attachment and entry by membrane fusion., Antibodies that bind but fail to neutralize noncognate serotypes enhance, infection. We have determined the crystal structure of a soluble fragment, of the envelope glycoprotein E from dengue virus type 3. The structure, closely resembles those of E proteins from dengue type 2 and tick-borne, encephalitis viruses. Serotype-specific neutralization escape mutants in, dengue virus E proteins are all located on a surface of domain III, which, has been implicated in receptor binding. While antibodies against epitopes, in domain I are nonneutralizing in dengue virus, there are neutralizing, antibodies that recognize serotype-conserved epitopes in domain ... [(full description)]
About this Structure
1UZG is a [Single protein] structure of sequence from [Dengue virus type 1] with FUL, BMA and NAG as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, J Virol. 2005 Jan;79(2):1223-31. PMID:15613349
Page seeded by OCA on Tue Oct 30 11:21:09 2007
Categories: Dengue virus type 1 | Single protein | Harrison, S.C. | Modis, Y. | BMA | FUL | NAG | Atp-binding | Class 2 fusion protein | Dengue virus | Envelope protein | Flavivirus | Fusion loop | Glycoprotein | Helicase | Hydrolase | Membrane fusion | Nonstructural protein | Polyprotein | Rna-directed rna polymerase | Transferase | Transmembrane | Virus/viral protein
