1jlm
From Proteopedia
|
I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND
Overview
BACKGROUND: Integrins are plasma membrane proteins that mediate adhesion, to other cells and to components of the extracellular matrix. Most, integrins are constitutively inactive in resting cells, but are rapidly, and reversibly activated in response to agonists, leading to highly, regulated cell adhesion. This activation is associated with conformational, changes in their extracellular portions, but the nature of the structural, changes that lead to a change in adhesiveness is not understood. The, interactions of several integrins with their extracellular ligands are, mediated by an A-type domain (generally called the I-domain in integrins)., Binding of the I-domain to protein ligands is dependent on divalent, cations. We have described previously the structure of the I-domain from, ... [(full description)]
About this Structure
1JLM is a [Single protein] structure of sequence from [Homo sapiens] with MN as [ligand]. Full crystallographic information is available from [OCA].
Reference
Two conformations of the integrin A-domain (I-domain): a pathway for activation?, Lee JO, Bankston LA, Arnaout MA, Liddington RC, Structure. 1995 Dec 15;3(12):1333-40. PMID:8747460
Page seeded by OCA on Mon Oct 29 15:50:17 2007
