2nqc
From Proteopedia
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Crystal structure of ig-like domain 23 from human filamin C
Overview
Filamin C is a dimeric, actin-binding protein involved in organization of, cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ultracentrifugation, experiments on the constructs containing carboxy-terminal domains of the, protein (domains 23-24 and 19-21). The crystal structure of domain 23 of, filamin C showed that the protein adopts the expected immunoglobulin, (Ig)-like fold. Small-angle X-ray scattering experiments performed on, filamin C tandem Ig-like domains 23 and 24 reveal a dimer that is formed, by domain 24 and that domain 23 has little interactions with itself or, with domain 24, while the analytical ultracentrifugation experiments, showed that the filamin C domains 19-21 form elongated monomers in diluted, solutions.
About this Structure
2NQC is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer., Sjekloca L, Pudas R, Sjoblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylanne J, Carugo KD, J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20. PMID:17379241
Page seeded by OCA on Wed Jan 23 13:39:38 2008
Categories: Homo sapiens | Single protein | Carugo, O. | Djinovic-Carugo, K. | Kiema, T.R. | Konarev, P. | Pudas, R. | Rybin, V. | Sjekloca, L. | Sjoeblom, B. | Svergun, D. | Ylanne, J. | GOL | IMD | NI | Filamin | Immune system | Immunoglobulin | Metal binding
