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2phw
From Proteopedia
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Pterocarpus angolensis lectin (PAL) in complex with Man-9
Overview
The crystal structure of Pterocarpus angolensis seed lectin is presented, in complex with a series of high mannose oligosaccharides ranging from, Man-5 to Man-9. Despite that several of the nine mannose residues of Man-9, have the potential to bind in the monosaccharide binding site, all, oligomannoses are bound in the same unique way employing the, tetrasaccharide sequence, Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-. ITC titration, experiments using Man-5, Man-9 and the Man-9-containing glycoprotein, soybean agglutinin as ligands confirm the monovalence of Man-9 and show a, four times higher affinity for Man-9 when it is presented to Pterocarpus, angolensis seed lectin in a glycoprotein context.
About this Structure
2PHW is a Single protein structure of sequence from Pterocarpus angolensis with and as ligands. Full crystallographic information is available from OCA.
Reference
How a Plant Lectin Recognizes High Mannose oligosaccharides., Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R, Plant Physiol. 2007 Jun 7;. PMID:17556509
Page seeded by OCA on Wed Jan 23 13:43:38 2008
Categories: Pterocarpus angolensis | Single protein | Buts, L. | Garcia-Pino, A. | Imberty, A. | Loris, R. | Wyns, L. | CA | MN | Carbohydrate | High mannose | Lectin
