Colicin M

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PDB ID 2xmx

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2xmx, resolution 1.67Å ()
Ligands: ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


Colicin M is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them by inhibiting synthesis of peptidoglycan - murein, preventing synthesis of the cell wall and ultimately leading to cell lysis.


Contents

Synthesis and release

Mechanism of uptake

Killing Activities

ColM shows enzymatic properties of degradation of lipid I and lipid II peptidoglycan intermediates. The cleavage occurs between the lipid moiety and the pyrophosphoryl groups. This then leads to the arrest of peptidoglycan polymerisation[1], rather than the direct degradation of the peptidoglycan[2].

References

  1. ↑ El Ghachi M, Bouhss A, Barreteau H, Touze T, Auger G, Blanot D, Mengin-Lecreulx D. Colicin M exerts its bacteriolytic effect via enzymatic degradation of undecaprenyl phosphate-linked peptidoglycan precursors. J Biol Chem. 2006 Aug 11;281(32):22761-72. Epub 2006 Jun 15. PMID:16777846 doi:10.1074/jbc.M602834200
  2. ↑ Schaller K, Dreher R, Braun V. Structural and functional properties of colicin M. J Bacteriol. 1981 Apr;146(1):54-63. PMID:7012126

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Gemma McGoldrick, Michal Harel

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