Colicin M

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PDB ID 2xmx

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2xmx, resolution 1.67Å ()
Ligands: ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


Colicin M is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them by inhibiting synthesis of peptidoglycan - murein, preventing synthesis of the cell wall and ultimately leading to cell lysis. of Colicin M.


Contents

Synthesis and release

Mechanism of uptake

Killing Activities

ColM shows enzymatic properties of degradation of lipid I and lipid II peptidoglycan intermediates. The cleavage occurs between the lipid moiety and the pyrophosphoryl groups. This then leads to the arrest of peptidoglycan polymerisation[1], rather than the direct degradation of the peptidoglycan[2].

References

  1. ↑ El Ghachi M, Bouhss A, Barreteau H, Touze T, Auger G, Blanot D, Mengin-Lecreulx D. Colicin M exerts its bacteriolytic effect via enzymatic degradation of undecaprenyl phosphate-linked peptidoglycan precursors. J Biol Chem. 2006 Aug 11;281(32):22761-72. Epub 2006 Jun 15. PMID:16777846 doi:10.1074/jbc.M602834200
  2. ↑ Schaller K, Dreher R, Braun V. Structural and functional properties of colicin M. J Bacteriol. 1981 Apr;146(1):54-63. PMID:7012126

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Gemma McGoldrick, Michal Harel

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