3q32

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Template:STRUCTURE 3q32

Structure of Janus kinase 2 with a pyrrolotriazine inhibitor

Template:ABSTRACT PUBMED 21282055

About this Structure

3q32 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Harikrishnan LS, Kamau MG, Wan H, Inghrim JA, Zimmermann K, Sang X, Mastalerz HA, Johnson WL, Zhang G, Lombardo LJ, Poss MA, Trainor GL, Tokarski JS, Lorenzi MV, You D, Gottardis MM, Baldwin KF, Lippy J, Nirschl DS, Qiu R, Miller AV, Khan J, Sack JS, Purandare AV. Pyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3. Bioorg Med Chem Lett. 2011 Jan 11. PMID:21282055 doi:10.1016/j.bmcl.2011.01.022

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