Alendronate

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Alendronate (Fosamax®)

Alendronate is commonly known for its use in treatment and prevention of osteoporosis in postmenopausal women and men, but is also used to treat Paget's disease (disease that results in deformed and enlarged bones).[1] Alendronate belongs to the class of nitrogen-containing bisphosphonates, which are inorganic pyrophosphate analogues.

History of Bisphosphonates

Bisphosphonates were first synthesized in Germany in 1865, but were not studied biologically until 1968. In the interim time, they were used in the textile and fertilizer industries due to their apparent inhibitory effect on calcium carbonate. However, in 1968, a group in Switzerland discovered bisphosphonates in humans after finding inorganic pyrophosphates which inhibited calcium phosphate precipitate in urine and plasma.[2]

Structure

Target Protein

FPPS Asymmetric unit

Drag the structure with the mouse to rotate


Side affects of Drug





References


  1. ↑ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000018/
  2. ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138713/?tool=pmcentrez

Proteopedia Page Contributors and Editors (what is this?)

Anne Goodling, David Canner, Justin Myles Kidd, OCA

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