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| This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
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Aldose Reductase (2IKH)
Wikipedia
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Policosanol, a well-defined mixture of very long chain primary alcohols that is available as a nutraceutical product, has been reported to lower blood cholesterol levels.[1]
In summary, this study provides the platform for further structure-guided design hypotheses of novel drug candidates with higher affinity and selectivity.[2]
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{{Information |Description=Cartoon diagram of human Template:W in complex with NADP+, Template:W, and IDD594, a small molecule inhibitor.
Created using
References
- ↑ Banerjee S, Ghoshal S, Porter TD. Activation of AMP-kinase by Policosanol Requires Peroxisomal Metabolism. Lipids. 2011 Feb 27. PMID:21359855 doi:10.1007/s11745-011-3540-6
- ↑ Steuber H, Heine A, Klebe G. Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution. J Mol Biol. 2007 May 4;368(3):618-38. Epub 2006 Dec 15. PMID:17368668 doi:10.1016/j.jmb.2006.12.004
