Sandbox 80

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Template:Tims Sandbox Reservation

Contents

Saquinavir

This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles.


PDB ID 3oxc

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3oxc, resolution 1.16Å ()
Ligands: , ,
Gene: pol (Human immunodeficiency virus 1)
Activity: HIV-1 retropepsin, with EC number 3.4.23.16
Related: 2ien, 3mws, 3nu3, 3cyx, 3d1x, 3d1y, 2nmy, 2nmz, 2nnk, 2nnp


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure

The chemical formula of is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol.

Protein and Drug interations

intermolecular forces attraction

References

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction

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