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3g4a

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Image:3g4a.png

Template:STRUCTURE 3g4a

Crystal structure of flavine dependant thymidylate synthase S88A mutant from Thermotoga maritima at 1.95 angstrom resolution

Template:ABSTRACT PUBMED 19370033

About this Structure

3g4a is a 4 chain structure with sequence from Thermotoga maritima msb8. Full crystallographic information is available from OCA.

Reference

  • Koehn EM, Fleischmann T, Conrad JA, Palfey BA, Lesley SA, Mathews II, Kohen A. An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene. Nature. 2009 Apr 16;458(7240):919-23. PMID:19370033 doi:10.1038/nature07973
  • Mathews II, Deacon AM, Canaves JM, McMullan D, Lesley SA, Agarwalla S, Kuhn P. Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein. Structure. 2003 Jun;11(6):677-90. PMID:12791256
  • Agrawal N, Lesley SA, Kuhn P, Kohen A. Mechanistic studies of a flavin-dependent thymidylate synthase. Biochemistry. 2004 Aug 17;43(32):10295-301. PMID:15301527 doi:10.1021/bi0490439

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