2i9s
From Proteopedia
|
The solution structure of the core of mesoderm development (MESD).
Overview
Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as, a molecular chaperone for receptors of the low-density lipoprotein, receptor (LDLR) family. By recording (15)N-HSQC-NMR spectra of six, different MESD constructs, we could determine a highly structured core, region corresponding to residues 104-177. Here we firstly present the, solution structure of this highly conserved core of MESD. It shows a, four-stranded anti-parallel beta-sheet and two alpha-helices situated on, one side of the sheet. Although described in the literature as, structurally homologues to ferredoxins, the connectivity of secondary, structure elements is different in the MESD fold. A structural comparison, to entries of the PDB reveals a frequent domain with low sequence homology, annotated as HMA and P-II domains in Pfam.
About this Structure
2I9S is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family., Kohler C, Andersen OM, Diehl A, Krause G, Schmieder P, Oschkinat H, J Struct Funct Genomics. 2007 Mar 7;. PMID:17342452
Page seeded by OCA on Wed Jan 23 14:22:52 2008
