2dw2

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Image:2dw2.jpg

2dw2, resolution 2.7Å

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Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal)

Overview

Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a, metalloproteinase from Crotalus atrox venom, possessing, metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the, typical domain architecture of a disintegrin and metalloproteinase, (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal, structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the, monomeric class of this family of proteins. The overall structures show, good agreement with both monomers of atypical homodimeric VAP1. Comparison, of the six catrocollastatin/VAP2B monomer structures and the structures of, VAP1 reveals a dynamic, modular architecture that may be important for the, functions of ADAM/adamalysin/reprolysin family proteins.

About this Structure

2DW2 is a Single protein structure of sequence from Crotalus atrox with and as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:17485084

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