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2wcx

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Revision as of 22:43, 14 March 2011 by OCA (Talk | contribs)
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Image:2wcx.png

Template:STRUCTURE 2wcx

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE IN COMPLEX WITH THIENOPYRROLE-BASED FINGER-LOOP INHIBITORS

Template:ABSTRACT PUBMED 19672916

About this Structure

2wcx is a 1 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Martin Hernando JI, Ontoria JM, Malancona S, Attenni B, Fiore F, Bonelli F, Koch U, Di Marco S, Colarusso S, Ponzi S, Gennari N, Vignetti SE, Rico Ferreira MD, Habermann J, Rowley M, Narjes F. Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase. ChemMedChem. 2009 Aug 11. PMID:19672916 doi:10.1002/cmdc.200900184
  • Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfi A. Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site. J Biol Chem. 2005 Aug 19;280(33):29765-70. Epub 2005 Jun 13. PMID:15955819 doi:http://dx.doi.org/10.1074/jbc.M505423200

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OCA

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