2xpk

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Image:2xpk.jpg

Template:STRUCTURE 2xpk

CELL-PENETRANT, NANOMOLAR O-GLCNACASE INHIBITORS SELECTIVE AGAINST LYSOSOMAL HEXOSAMINIDASES

Template:ABSTRACT PUBMED 21095575

About this Structure

2xpk is a 2 chain structure with sequence from Clostridium perfringens. Full crystallographic information is available from OCA.

Reference

  • Dorfmueller HC, Borodkin VS, Schimpl M, Zheng X, Kime R, Read KD, van Aalten DM. Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases. Chem Biol. 2010 Nov 24;17(11):1250-5. PMID:21095575 doi:10.1016/j.chembiol.2010.09.014

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