2ds1
From Proteopedia
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Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor
Overview
The design of a novel series of cyclin-dependent kinase (CDK) inhibitors, containing a macrocyclic quinoxaline-2-one is reported. Structure-based, drug design and optimization from the starting point of diarylurea 2, which we previously reported as a moderate CDK1,2,4,6 inhibitor [J., Biol.Chem.2001, 276, 27548], led to the discovery of potent CDK1,2,4,6, inhibitor that were suitable for iv administration for in vivo study.
About this Structure
2DS1 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Cyclin-dependent kinase, with EC number 2.7.11.22 Full crystallographic information is available from OCA.
Reference
Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure., Kawanishi N, Sugimoto T, Shibata J, Nakamura K, Masutani K, Ikuta M, Hirai H, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5122-6. Epub 2006 Jul 28. PMID:16876403
Page seeded by OCA on Wed Jan 23 14:48:18 2008
