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Chorismate synthase

spinqualitylabelsall models PDB ID 1ztb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1ztb, resolution 2.65Å ()
Gene:	aroC, aroF (Mycobacterium tuberculosis)
Activity:	Chorismate synthase, with EC number 4.2.3.5
Structural annotation: Resources: InterPro : Ipr000453 Pfam : PF01264 UniProt : P63611
Functional annotation: Biological process: amino acid biosynthetic process aromatic amino acid family biosynthetic process Molecular function: lyase activity chorismate synthase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Chorismate synthase 2 Structure 2.1 Function 3 Mechanism 4 References

Chorismate Synthase is the last enzyme present in the shikimate pathway^[1], a process which converts phosphoenolpyruvate, and erythrose 4-phosphate to chorismate in a series of seven steps.^[2] The shikimate pathway is essential in the production of the amino acids phenylalanine, tryptophan and tyrosine, all essential amino acids.^[3]

Structure

spinqualitylabelsall models Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

^[4]

Function

Mechanism

References

1. ↑ Macheroux P, Schmid J, Amrhein N, Schaller A. A unique reaction in a common pathway: mechanism and function of chorismate synthase in the shikimate pathway. Planta. 1999 Jan;207(3):325-34. PMID:9951731
2. ↑ Herrmann KM, Weaver LM. THE SHIKIMATE PATHWAY. Annu Rev Plant Physiol Plant Mol Biol. 1999 Jun;50:473-503. PMID:15012217 doi:10.1146/annurev.arplant.50.1.473
3. ↑ Dias MV, Borges JC, Ely F, Pereira JH, Canduri F, Ramos CH, Frazzon J, Palma MS, Basso LA, Santos DS, de Azevedo WF Jr. Structure of chorismate synthase from Mycobacterium tuberculosis. J Struct Biol. 2006 May;154(2):130-43. Epub 2006 Jan 17. PMID:16459102 doi:10.1016/j.jsb.2005.12.008
4. ↑ Ahn HJ, Yoon HJ, Lee B 2nd, Suh SW. Crystal structure of chorismate synthase: a novel FMN-binding protein fold and functional insights. J Mol Biol. 2004 Feb 27;336(4):903-15. PMID:15095868