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Sandbox Reserved 336
From Proteopedia
| This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada. |
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| 1hvy, resolution 1.90Å () | |||||||||
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| Ligands: | , , | ||||||||
| Non-Standard Residues: | |||||||||
| Activity: | Thymidylate synthase, with EC number 2.1.1.45 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Thymidylate Synthase
Thymidylate Synthase is a protein found in all organisms that make DNA. Thymidylate Synthase (TS) is the essential enzyme that catalyzes the formation of dTMP from dUMP, using 5,10-methylenetetrahydrofolate (mTHF) as a cosubstrate.Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.[1] Wikipedia
Overview
Thymidylate Synthase catalyzes the reductive methylation of deoxyuridylic acid during the de novo synthesis of thymidylic acid (Jenh et al., 1985). This reaction occurs primarily during the S phase of the cell cycle. TS is an essential enzyme in proliferating cells that are not supplied with an alternate source of thymidine nucleotides. Research has shown tat TS enzyme levels are much higher in rapidly proliferating cells than in non dividing cells (Jenh et al., 1985).
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