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spinqualitylabelsall models PDB ID 1bzy Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1bzy, resolution 2.00Å ()
Ligands:	, ,
Activity:	Hypoxanthine phosphoribosyltransferase, with EC number 2.4.2.8
Structural annotation: Resources: CATH : 1Bzya00, 1Bzyb00, 1Bzyc00, 1Bzyd00 InterPro : Ipr005904, Ipr002375, Ipr000836 Pfam : PF00156 SCOP : d1bzya_, d1bzyb_, d1bzyc_, d1bzyd_ UniProt : P00492
Functional annotation: Cellular component: cytoplasm Biological process: purine nucleotide biosynthetic process purine ribonucleoside salvage nucleoside metabolic process hypoxanthine metabolic process protein homotetramerization behavior positive regulation of dopamine metabolic process Molecular function: transferase activity, transferring glycosyl groups hypoxanthine phosphoribosyltransferase activity protein binding protein homodimerization activity transferase activity magnesium ion binding metal ion binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Introduction 2 Section 1.1 3 Section 1.2 4 References

Introduction

Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a key enzyme in purine salvage pathways. This enzyme salvages guanine directly and adenine indirectly from catabolism. It catalyzes the reversible transfer of the phosphoribosyl group from a-D-5-phosphoribosyl 1-pyrophosphate (PRPP) to hypoxanthine or guanine forming either IMP or GMP, respectively. This reaction is dependent on a divalent magnesium cation. HGPRT is deficient in Lesch-Nyhan syndrome, a sever neurological disorder characterized by high levels of blood uric acid and uncontrollable self mutilation. A partial deficiency of the enzyme leads to gouty arthritis [1]

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Section 1.1

jjhjh RCSB Protein Data Bank ^[1]

Section 1.2

Text to display

References

1. ↑ ^{1.0 1.1} Shi W, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC. The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. Nat Struct Biol. 1999 Jun;6(6):588-93. PMID:10360366 doi:http://dx.doi.org/10.1038/9376