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1 Phosphomannose mutase 2
- 1.1 Background
2 How does PMM2 work?
3 Structure

Phosphomannose mutase 2

Background

Phosphomannose mutase 2,2amy

. Phosphomannose mutase 2 is an cytosolic enzyme which is critical in the conversion of mannose-6-phosphate into mannose-1-phosphate. It's a homodimeric protein, having two identical subunits working as independent domains. It's a typical HAD superfamily protein, which has the characteristic "cap" and "core" domains.

How does PMM2 work?

Structure

2amy, resolution 2.09Å ()

Ligands:

Non-Standard Residues:

Gene:

HS.459855 (Homo sapiens)

Activity:

Phosphomannomutase, with EC number 5.4.2.8

Structural annotation:
Resources:	InterPro : Ipr005002, Ipr006379 Pfam : PF03332 UniProt : O15305

Functional annotation:
Cellular component:	cytoplasm
Biological process:	GDP-mannose biosynthetic process mannose biosynthetic process protein amino acid N-linked glycosylation protein amino acid glycosylation metabolic process
Molecular function:	phosphomannomutase activity isomerase activity catalytic activity