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Histone Acetyltransferase GCN5

Histone Acetyltransferase (HAT) GCN5 is a ~94 kD (837 amino acid) protein. It is a nuclear HAT or A-type HAT.

GCN5 catalyzes the acetylation of specific Lysine residues of histones H3 and H4. Histone acetylation is an important




HAT Domain

The HAT domain of human GCN5 consists of amino acid residues 496-658. This domain is a mixed alpha beta structure with 7 alpha helices and seven anti-parallel beta strands.


Catalysis






Bromo Domain



References

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Jamie Abbott

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