Sandbox11

From Proteopedia

proteopedia linkproteopedia link

This sandbox is in use until August 1, 2011 for UMass Chemistry 423. Others please do not edit this page. Thanks!

Chem423 Team Projects: Understanding Drug Mechanisms

Andy Kim, Zach Brentzel, Tyler Vlass, Zach Hitzig

spinqualitylabelsall models PDB ID 1acj Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1acj, resolution 2.80Å ()
Ligands:
Activity:	Acetylcholinesterase, with EC number 3.1.1.7
Structural annotation: Resources: CATH : 1Acj000 InterPro : Ipr002018, Ipr000908, Ipr000997 Pfam : PF00135 SCOP : d1acj__ UniProt : P04058
Functional annotation: Cellular component: cell junction membrane synapse Biological process: neurotransmitter catabolic process acetylcholine catabolic process in synaptic cleft Molecular function: GPI anchor binding cholinesterase activity acetylcholinesterase activity hydrolase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Topic: Acetylcholinesterase bound by Tacrine 2 Introduction 3 Overall structure 4 Binding 5 Additional Features 6 This is a placeholder

Topic: Acetylcholinesterase bound by Tacrine

Introduction

By Tyler Vlass

Overall structure

By Zach Brentzel

spinqualitylabelsall models PDB ID 1ea5 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1ea5, resolution 1.80Å ()
Ligands:
Activity:	Acetylcholinesterase, with EC number 3.1.1.7
Related:	1amn, 1ax9, 1cfj, 1dx6, 1e3q, 1e66, 1eea, 1eve, 1fss, 1oce, 1qid, 1qie, 1qif, 1qig, 1qih, 1qii, 1qij, 1qik, 1qim, 1qti, 1som, 1vot, 1vxo, 1vxr, 2ace, 2ack, 2dfp, 3ace
Structural annotation: Resources: CATH : 1Ea5A00 InterPro : Ipr000908, Ipr000997, Ipr019826, Ipr019819, Ipr002018 Pfam : PF00135 SCOP : d1ea5a_
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

¤Acetylcholinesterase (AChE) is a tetramer. Bound to the membrane in neuromuscular junctions. [[1]] ¤In , it can be seen that there are X alpha helices and 14 beta strands. There are 2 beta sheets formed from 3 anti-parallel and 11 anti-parallel beta sheets, respectively(maybe highlight with green scene).

Copy and paste the following line where you want the scene link to appear (scroll down if needed) and edit the TextToBeDisplayed:

Binding

By Andy Kim==

Additional Features

By Zach Hitzig

This is a placeholder

This is a placeholder text to help you get started in placing a Jmol applet on your page. At any time, click "Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load and display another structure.

Andy Kim, Zach Brentzel, Tyler Vlass, Zach Hitzig-Acetylcholinesterase