Ton

From Proteopedia

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Contents 1 Structure 2 Function 3 Interaction of Ton proteins 4 Interaction with Colicin 5 Regulation 6 References

Structure

The Ton system comprises of the triumvirate TonB/ExbB/ExbD inner membrane complex.

Function

The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell.

Interaction of Ton proteins

Like in the Tol complex, the Ton system proteins interact with each other:

1. the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein
2. ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction^[2]

Interaction with Colicin

The Ton proteins regularly interact with colicins.

Regulation

References

1. ↑ Witty M, Sanz C, Shah A, Grossmann JG, Mizuguchi K, Perham RN, Luisi B. Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein. EMBO J. 2002 Aug 15;21(16):4207-18. PMID:12169623
2. ↑ Higgs PI, Myers PS, Postle K. Interactions in the TonB-dependent energy transduction complex: ExbB and ExbD form homomultimers. J Bacteriol. 1998 Nov;180(22):6031-8. PMID:9811664