Pal

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Contents

Structure

Pal is a lipoprotein which is anchored in the outer membrane. Synthesised as a precursor of 173 amino acids, it contains a signal sequence including an LVAC motif, with the flexible N-terminal tail binding to the inner leaflet of the outer membrane[1]

Pal forms a complex with TolB (see TolB)

Periplasmic Domain of Pal

Template:STRUCTURE 1oap

Function

During translocation, signal peptidase II cleaves the LVAC motif, and the localisation of Pal is dependent on the Lol protein system[2]


References

  1. ↑ Godlewska R, Wisniewska K, Pietras Z, Jagusztyn-Krynicka EK. Peptidoglycan-associated lipoprotein (Pal) of Gram-negative bacteria: function, structure, role in pathogenesis and potential application in immunoprophylaxis. FEMS Microbiol Lett. 2009 Sep;298(1):1-11. Epub 2009 May 21. PMID:19519769 doi:10.1111/j.1574-6968.2009.01659.x
  2. ↑ . PMID: 19519769

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Michal Harel, Laura McCauley, Joel L. Sussman

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