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244d

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Image:244d.jpg

244d, resolution 1.200Å

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THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX

Overview

Repeat tracts of guanine bases found in DNA and RNA can form tetraplex, structures in the presence of a variety of monovalent cations. Evidence, suggests that guanine tetraplexes assume important functions within, chromosomal telomeres, immunoglobulin switch regions, and the human, immunodeficiency virus genome. The structure of a parallel-stranded, tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium, cations was determined by x-ray crystallography to 1.2 angstroms, resolution. Sharply resolved sodium cations were found between and within, planes of hydrogen-bonded guanine quartets, and an ordered groove, hydration was observed. Distinct intra- and intermolecular stacking, arrangements were adopted by the guanine quartets. Thymine bases were, exclusively involved in making extensive lattice contacts.

About this Structure

244D is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.

Reference

The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:8036494

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