293d

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spinqualitylabelsall models 293d, resolution 1.000Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

INTERACTION BETWEEN THE LEFT-HANDED Z-DNA AND POLYAMINE-2: THE CRYSTAL STRUCTURE OF THE D(CG)3 AND SPERMIDINE COMPLEX

Overview

This paper deals with the crystal structure of d(CG)3-spermidine complex., The DNA fragment, d(CG)3, was crystallized with, N-(2-amino-propyl)-1,4-diamino-butane, PA(34), spermidine. The results of, its X-ray crystallographic analysis showed many intermolecular contacts, between d(CG)3 and spermidine, but the binding mode of spermidine to the, d(CG)3 molecule is different from that of the d(CG)3 and, N-(2-amino-ethyl)-1,4-diamino-butane [PA(24)] complex: a spermidine, molecule bound to the d(CG)3 and its symmetrically related neighboring, d(CG)3 molecules through the water molecules with hydrogen bonds, while, one PA(24) molecule connected directly to one d(CG)3 molecule, but not to, its neighboring d(CG)3 molecule. In the crystal, the d(CG)3 molecule was, the left-handed Z-form, and three magnesium cations and a sodium cation, were observed around the d(CG)3 moiety with different binding modes from, the case of the d(CG)3-PA(24) complex.

About this Structure

293D is a Protein complex structure of sequences from [1] with , and as ligands. Full crystallographic information is available from OCA.

Reference

Interaction between the left-handed Z-DNA and polyamine-2. The crystal structure of the d(CG)3 and spermidine complex., Ohishi H, Nakanishi I, Inubushi K, van der Marel G, van Boom JH, Rich A, Wang AH, Hakoshima T, Tomita K, FEBS Lett. 1996 Aug 5;391(1-2):153-6. PMID:8706905

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