User:Jan Panteli/sandbox 1

From Proteopedia

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E. Coli D- Ribose Binding Protein (RBP) is involved in signal transduction of the chemokine D-ribose to stimulate chemotaxis in the bacteria.

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.

Exploring the Structure

spinqualitylabelsall models Open Conformation of E. Coli D-Ribose Binding Protein for signal transduction of Chemotaxis machinery RBP(1URP) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

There are four domains to RBP, A,B,C,and D. These domains form a binding site for d-ribose and the bound form of the protein then interacts with transmembrane protein Trg, the chemotaxis transducer for d-ribose.

spinqualitylabelsall models Closed conformation of the RBP upon binding with ligand, D-Ribose in Domain A Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image