2a4r

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Image:2a4r.gif

2a4r, resolution 2.40Å

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HCV NS3 Protease Domain with a Ketoamide Inhibitor Covalently bound.

Overview

Modification of the P(2) and P(1) side chains of earlier P(3)-capped, alpha-ketoamide inhibitor of HCV NS3 serine protease 1 resulted in the, discovery of compound 24 with about 10-fold improvement in potency.

About this Structure

2A4R is a Protein complex structure of sequences from Hepatitis c virus with and as ligands. Full crystallographic information is available from OCA.

Reference

Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency., Bogen S, Saksena AK, Arasappan A, Gu H, Njoroge FG, Girijavallabhan V, Pichardo J, Butkiewicz N, Prongay A, Madison V, Bioorg Med Chem Lett. 2005 Oct 15;15(20):4515-9. PMID:16112862

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