Cathepsin
From Proteopedia
Cathepsin (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, i.e. the crystal structure of wild-type human procathepsin B (1pbh).
3D Structures of Cathepsin
Update June 2011
Procathepsin-B
1pbh, 2pbh, 3pbh – hPCTSB - human
1mir - rPCTSB (mutant) - rat
Cathepsin-B mature
3hhi – TbCTSB (mutant) residues 23-340+CA074 – Trypanosoma brucei
3k9m – hMCTSB+stefin A
3ai8 – hMCTSB + antibiotic
2ipp, 1huc – hMCTSB
3cbj, 3cbk – hMCTSB (mutant)+chagasin
2dc6, 2dc7, 2dc8, 2dc9, 2dca, 2dcb, 2dcc, 2dcd – bMCTSB+inhibitor – bovine
1sp4, 1csb – bMCTSB+epoxysuccinyl inhibitor
1ito, 1qdq – bMCTSB +inhibitor
1gmy - bMCTSB +dipeptidyl nitrile
1the – rMCTSB (mutant)+butanone inhibitor – rat
1cpj - rMCTSB (mutant)
1cte - rMCTSB+pyrimidine inhibitor
Cathepsin-C mature
2djf, 2djg – hMCTSC +Gly-Phe-CHN2
1jqp – rMCTSC
1k3b – hMCTSC
Cathepsin-D mature
1lyw, 1lya – hMCTSD
1lyb - hMCTSD+pepstatin
Cathepsin-E mature
1tzs – hMCTSE+activation peptide from CTSE
Cathepsin-F mature
1m6d – hMCTSF+piperidine inhibitor
Cathepsin-G mature
1kyn – hMCTSG +naphthalene inhibitor
1au8, 1cgh - hMCTSG +phosphonate inhibitor
1t32 - hMCTSG +piperidine inhibitor
Cathepsin-H mature
1nb3, 1nb5 – pMCTSH +stefin A – pig
8pch - pMCTSH
Cathepsin-K mature
3o1g, 3n3g, 2r6n, 1bgo, 3kwz, 3kx1, 3o0u – hMCTSK+ pyrimidine inhibitor
3mpe, 3mpf – hMCTSK (mutant) + pyrimidine inhibitor
3h7d - hMCTSK (mutant) + chondroitin-4-sulfate
3c9e - hMCTSK + chondroitin-4-sulfate
3kwb - hMCTSK (mutant)+dioxo-triazine
3kw9 - hMCTSK +triazine
1yk8 - hMCTSK + cyanamide inhibitor
1yt7 - hMCTSK + ketoamide inhibitor
2aux, 2auz - hMCTSK + semicarbazone inhibitor
1ayu, 1ayv, 1ayw - hMCTSK + carbohydrazide inhibitor
2bdl, 1yk7, 1tu6, 1au3, 1au4 - hMCTSK + pyrrolidine inhibitor
1snk - hMCTSK + norleucine inhibitor
1nl6, 1nlj - hMCTSK+ azepanone inhibitor
1q6k - hMCTSK+carbamate inhibitor
1au0 - hMCTSK+ diacylaminoethyl ketone inhibitor
1au2 - hMCTSK+ propanone inhibitor
1atk – hMCTSK+guanidine inhibitor
1vsn - hMCTSK+ inhibitor
2ato – hMCTSK+myocrisin
1u9v, 1u9x, 1mem – hMCTSK+piperazine inhibitor
1u9w - hMCTSK+imidazole inhibitor
2ftd – MCTSK+azepan inhibitor – Macaca mulatta
2f7d – MCTSK (mutant)+nitrile inhibitor - rabbit
Procathepsin-L
Cathepsin-L mature
3f75 – MCTSL +CTSL propeptide – Toxoplasma gondii
2p86 – TbMCTSL +K11002
2nqd - CTSL residues 1-220 (mutant)+chagasin – Trypanosoma cruzi
1mhw – hMCTSL +tripeptide
1icf – hMCTSL +MHC class II fragment
Procathepsin-L1
2o6x – hPCTSL1 (mutant) – Fasciola hepatica
Cathepsin-L1 mature
3iv2 – hMCTSL1 (mutant)
3k24 - hMCTSL1 (mutant) +tripeptide
3of8 - hMCTSL1 + dipeptidyl inhibitor
2xu1, 2xu3, 2xu4, 2xu5 - hMCTSL1 catalytic domain (mutant)+nitrile inhibitor
3bc3, 3of9 - hMCTSL1 +inhibitor
3h89, 3h8b, 3h8c - hMCTSL1 (mutant) + retro-binding inhibitor
3hwn, 3hha – hMCTSL1+pyrazole inhibitor
3kse – hMCTSL1 (mutant)+stefin
Cathepsin-L2 mature
3h6s – hMCTSL2+clitocypin
1fh0 – hMCTSL2 (mutant) +vinyl sulfone inhibitor
3kfq - hMCTSL2 (mutant)+stefin
Procathepsin-S
2c0y – hPCTSS (mutant)
Cathepsin-S mature
3n3g, 3n4c - hMCTSS+ pyrimidine inhibitor
3ovx - hMCTSS+ aldehyde inhibitor
3ovz - hMCTSS+ ketoamide inhibitor
3kwn – hMCTSS (mutant)+ thioether acetamide
3iej - hMCTSS (mutant)+pyrazole inhibitor
2h7j, 2hxz- hMCTSS+triazole inhibitor
2r9m, 2r9n, 2r9o – hMCTSS+piperidine inhibitor
2op3, 2hhn, 2g7y, 2hh5, 2f1g – hMCTSS+aryl inhibitor
2fud, 2fra, 2frq, 2ft2, 1npz, 1nqc – hMCTSS+inhibitor
2fye, 2g6d – hMCTSS (mutant)+inhibitor
2fq9, 1ms6 – hMCTSS +nitrile inhibitor
1glo - hMCTSS (mutant)
Procathepsin-X
1deu - hPCTSX
Cathepsin-X mature
1ef7 – hMCTSX
