Elastase

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Crystal structure of full-length human Elastase (Metalloproteinase-12), 3ba0

Elastase (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. The images at the left and at the right correspond to one representative elastase structure, i.e. the human Matrix Metalloproteinase-12 (MMP12), which is macrophage ELA (3ba0). Calcium ions are shown as green balls, zinc ions are grey balls and acetohydroxamic acid is shown as space filling object.

1 3D structures of elastase
2 MMP12
3 MMP16
4 ELA
5 ELA2

3D structures of elastase

Update June 2011

MMP12

3lka - hMMP12 catalytic domain+hydroxamic acid+paramethoxy-sulfonyl amide – human
3ba0, 1jk3 – hMMP12
3ehx, 3ehy, 1utt, 1utz, 1ros - hMMP12 catalytic domain+inhibitor
2oxu - hMMP12 catalytic domain
2oxw, 2oxz - hMMP12 catalytic domain+peptide
2hu6 - hMMP12 catalytic domain+bicyclic inhibitor
1rmz - hMMP12 catalytic domain+ inhibitor NNGH
1y93 - hMMP12 catalytic domain+acetohydroxamic acid
1jiz – hMMP12+ hydroxamic acid
1os2 - hMMP12 (mutant)+hydroxamic acid
1os9 - hMMP12 (mutant)
3f15, 3f16, 3f17, 3f18, 3f19, 3f1a, 3n2u, 3n2v, 3nx7 - hMMP12 catalytic domain+sulfonamide inhibitor
2w0d - hMMP12 catalytic domain (mutant)
2krj, 2k9c – hMMP12 fraction – NMR
2jxy - hMMP12 hemopexin-like domain – NMR
2k2g - hMMP12 catalytic domain+inhibitor – NMR
2poj - hMMP12 catalytic domain – NMR
2z2d - hMMP12 catalytic domain+butanoic acid – NMR
1ycm, 1z3j – hMMP12 (mutant)+hydroxamic acid derivative - NMR
3lk8 - hMMP12 catalytic domain (mutant)+hydroxamic acid derivative
2wo8, 2wo9, 2woa – hMMP12 fraction+hydroxy carboxylic acid
3lik, 3lil, 3lir, 3ljg – hMMP12 catalytic domain (mutant)+chelating inhibitor

MMP16

1rm8 – hMMP16+batimastat

ELA

3mty, 3mu0, 3mu1, 3mu4, 3mu5, 3mu8, 3mnb, 3mnc, 3mns, 3mnx, 3mo3, 3mo6, 3mo9, 3moc, 3e3t, 2v0b, 2g4t, 2g4u, 2de8, 2blo, 2blq, 2a7c, 2a7j, 1gvk, 1qnj, 1lvy, 3est, 1est, 2oqu, 3odd, 3odf – pELA1 – pig
3hgn – pELA1+peptidyl inhibitor – neutron
3hgp, 2cv3, 2bdb, 2bcd, 2h1u, 1mmj, 1h9l, 1nes, 4est, 5est, 8est, 7est, 6est - pELA1+peptidyl inhibitor
1fzz – pELA1+ONO-6818
1qr3, 1qgf, 1bru, 1hv7, 1btu – pELA1+cyclic inhibitor
1e34, 1e35, 1e36, 1e37, 1e38 – pELA1-gamma-lactam
1eai – pELA1+Ascaris inhibitor
2d26 – pELA1+α-1-antitrypsin
1fle – pELA1+elafin
1b0e, 1b0f – pELA1+MDL
2v35 – pELA1+JM54
2iot – pELA1+clavulanic acid
2de9 – pELA1+tris
1uvo, 1uvp, 1lka, 1lkb – pELA1+ions
1gwa – pELA1+I3
1uo6, 1c1m – pELA1+Xe
1l0z, 1l1g - pELA1+Xe+Br
2bb4, 2bd2, 2bd3, 2bd4, 2bd5, 2bd7, 2bd8, 2bd9, 1hax, 1hay, 1haz, 1hb0, 1qix – pELA1+beta-casomorphin-7
2bda – pELA1+N-acetyl-NPI
1mcv – pELA1+squash inhibitor
1bma – pELA1+aminimide
1elf, 1elg – pELA1+peptidyl hydroxylamine
1eld, 1ele, 1elb, 1ela, 1elc, 2est – pELA1+anilide inhibitor
1esa, 1esb – pELA1 intermediate
1eas, 1eat, 1eau – pELA1+pyridine inhibitor
1inc – pELA1+benzoxazinone
1jim, 9est, 8est – pELA1+coumarin derivative
2fo9, 2foa, 2fob, 2foc, 2fod, 2foe, 2fof, 2fog, 2foh – pELA1+solvent
3dbk – PaELA+phophoramidon – Pseudomonas aeruginosa
1u4g – PaELA+HPI
1ezm - PaELA
1elt – ELA - salmon

ELA2

3q76 – hELA2
3q77 – hELA2+dihydropyrimidone inhibitor
2z7f – hELA2 peptidase domain +antileukoproteinase
2rg3 – hELA2+sulfonic inhibitor
1h1b, 1ppg, 1hne – hELA2+inhibitor
1ppf – hELA2+ovomucoid
1b0f – hELA2+MDL101146