2f9a
From Proteopedia
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HMG-CoA synthase from Brassica juncea in complex with F-244
Overview
3-Hydroxy-3-methylglutaryl CoA synthase (HMGS) catalyzes the first, committed step in the mevalonate metabolic pathway for isoprenoid, biosynthesis and serves as an alternative target for cholesterol-lowering, and antibiotic drugs. We have determined a previously undescribed crystal, structure of a eukaryotic HMGS bound covalently to a potent and specific, inhibitor F-244, [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecad, ienenoic acid]. Given the accessibility of synthetic analogs of the F-244, natural product, this inhibited eukaryotic HMGS structure serves as a, necessary starting point for structure-based methods that may improve the, potency and species-specific selectivity of the next generation of F-244, analogs designed to target particular eukaryotic and prokaryotic HMGS.
About this Structure
2F9A is a Single protein structure of sequence from Brassica juncea with as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:16864776
Page seeded by OCA on Tue Jan 29 19:30:59 2008
Categories: Brassica juncea | Single protein | Ferrer, J.L. | Noel, J.P. | Pojer, F. | Richard, S.B. | F24 | F-244 | Hmgs1
