Ribosomal protein S13
From Proteopedia
Ribosomal protein S13 (RPS13) is one of the 22 proteins which belong to the small subunit of the bacterial ribosome. It is involved in binding to fMet-tRNA and hence to the translation initiation step. The images at the left and at the right correspond to one representative RPS13, i.e. the crystal structure of Ribosomal protein S13 from Thermus thermophilus (2zm6, chain M).
3D Structures of Ribosomal protein S13
Update June 2011
S13 in small ribosomal subunit
2zm6, 1n36, 1j5e, 3oto - TtRPS13 in 30S ribosomal subunit+THX+16S RRNA – Thermus thermophilus
2vqe, 2vqf, 2uuc, 2e5l, 2uu9, 2uua, 2uub, 3pyn, 3pyq, 3pys, 3pyu - TtRPS13 in 30S ribosomal subunit+16S RRNA+RNA fragment
3kc4 – EcRPS13 in 30S ribosomal subunit – Escherichia coli
3i1m, 3i1o, 3df1, 3df3, 2vho, 2vhp, 2avy, 2aw7, 1pnx, 3or9, 3ora - EcRPS13 in 30S ribosomal subunit+16S RRNA
1i94, 1fka - TtRPS13 in 30S ribosomal subunit+16S RRNA
1p87, 1p6g - EcRPS13 in 30S ribosomal subunit+16S RRNA – Cryo-EM
3bbn - RPS13 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach
S13 in small + large ribosomal subunit
1ml5 - EcRPS13 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM
S13 in small ribosomal subunit+ chain release factor
3mr8, 3ms0 – TtRPS13 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA
3d5a, 3d5c - TtRPS13 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA
2b64 - TtRPS13 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1
2b9m - TtRPS13 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2
2x9r, 2x9t, 2wh1, 2wh3 - TtRPS13 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA
3f1e, 3f1g - TtRPS13 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA
S13 in small ribosomal subunit+tRNA+mRNA
2hgi - TtRPS13 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet
2hgp - TtRPS13 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA
2i2p, 2i2u - EcRPS13 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA
2hgr - TtRPS13 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA
1yl4 – TtRPS13 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator
1pns - EcRPS13 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA
1xnq, 1xnr - TtRPS13 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA
S13 in small ribosomal subunit+A-site tRNA
2uxd, 2uxc - TtRPS13 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA
1n32, 1n33 - TtRPS13 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA
1n34 - TtRPS13 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA
1xmo, 1xmq - TtRPS13 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA
2uxb - TtRPS13 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA
S13 in small ribosomal subunit+P-site tRNA
3i8g - TtRPS13 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA
3i8h, 3i9b, 3i9d - TtRPS13 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA
1ibk - TtRPS13 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA
2wwl - EcRPS13 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - Escherichia coli
3i1q - EcRPS13 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA
3i1s, 3i1z, 3i21 - EcRPS12 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA
S13 in small ribosomal subunit+A-site tRNA+P-site tRNA
1ibl, 1ibm - TtRPS13 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA
S13 in small ribosomal subunit+P-site tRNA+E-site tRNA
2ow8 - TtRPS13 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA
2b9o - TtRPS13 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA
2qnh - TtRPS13 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA
S13 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA
2gy9, 2gyb - EcRPS13 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM
1jgo, 1jgp, 1jgq, 1gix - TtRPS13 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA
3e1a, 3e1c - EcRPS13 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA
S13 in small ribosomal subunit + antibiotics
1i95, 1i97, 2hhh, 2f4v, 3oge, 3ogy, 3ohc, 3ohd, 3ohy, 3oi0, 3oi2, 3oi4 - TtRPS13 in 30S ribosomal subunit+16S RRNA+antibiotic
1hnw, 1hnx, 1hnz, 1fjg - TtRPS13 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic
2qbb, 2qb9, 1vs5, 1vs7, 2qan, 2qal, 2qou, 2qow, 2qoy, 2qp0, 2z4k, 2z4m, 3oaq, 3oar, 3ofa, 3ofb, 3ofo, 3ofp, 3ofx, 3ofy - EcRPS13 in 30S ribosomal subunit+16S RRNA+antibiotic
2j00, 2j02 - TtRPS13 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA
2wdg, 2wdh, 2wdk, 2wdm - TtRPS13 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe+paromomycin
3knj, 3knh - TtRPS13 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin
3knl, 3knn - TtRPS13 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin
S13 in small ribosomal subunit + ribosome recycling factor
2qbd, 2qbf – EcRPS13 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor
3r8n, 3r8o – EcRPS12 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA
2qbh, 2qbj - EcRPS13 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin
2v46, 2v48 - TtRPS13 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet
S13 in small ribosomal subunit + elongation factor
2wri, 2wrk - TtRPS13 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G
2wrn, 2wrq - TtRPS13 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4
3fic - TtRPS13 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A
3izv – EcRPS13 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU
3izw – EcRPS13 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU
2y0u, 2y0w, 2y0y, 2y10, 2y12, 2y14, 2y16, 2y18 - TtRPS13 in 30S subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU
3fih - EcRPS13 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU
3huw, 3huy - TtRPS13 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P
1mj1 – EcRPS13+EcRPS12+EcRPL11+16S RRNA fragment+23S RRNA fragment+tRNA Phe+elongation factor TU – Cryo-EM
1s1h - yRPS13 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast
S13 in small ribosomal subunit + translation initiation factor
1i96 - TtRPS13 in 30S ribosomal subunit+THX+IF3+16S RRNA
1hr0 - TtRPS13 in 30S ribosomal subunit+THX+IF+16S RRNA
S13 in small ribosomal subunit + various proteins
3kiq, 3kis, 3kiu, 3kix - TtRPS13 in 30S ribosomal subunit+toxin RelE+16S RRNA
1voq, 1vos, 1vov, 1vox, 1voz - EcRPS13 in 30S ribosomal subunit+protein Y+16S RRNA
2xfz, 2xg1 - TtRPS13 in 30S ribosomal subunit+tRNA Phe+mRNA+colicin E3+16S RRNA
3jyv - RPS13+RPS0+RPS2+RPS3+RPS5+RPS9+RPS11+RPS14+RPS15+RPS16+RPS18+RPS20+RPS22+RPS23+RPS29+18S RRNA+RACK1+S19E+tRNA – Cryo-EM - Thermomyces lanuginosus
3j00 – EcRPS13 + 16S RRNA + FTSQ + apolipoprotein A-I
S13 in small 40S ribosomal subunit + various proteins
2zkq – RPS13 in 40S ribosomal subunit+RRNA fragments+RACK1+18S RRNA – dog – Cryo-EM
3iz6 - RPS13 in 40S ribosomal subunit +RACK1+18S RRNA – wheat – Cryo-EM
2o2z, 3o30 - yRPS13 in 40S ribosomal subunit +RACK1
S13 in part of small ribosomal subunit
2r1g – TtRPS13+ TtRPS9+ TtRPS12+ 16S RRNA fragment
3iyx, 3iyy - EcRPS13+ EcRPL5+ EcRPL31 – Cryo-EM
1ysh - RPS13+ RPL30+ RPL37+RNA fragments – Cryo-EM – Triticum aestivum
