Group:MUZIC:Calcineurin
From Proteopedia
The calcium/calmodulin-dependent phosphatase calcineurin is localized in the nucleus and in the Z-disc of muscle fibers. Its activity is controled by calcium signals that lead to remodeling of skeletal and cardiac muscle in response to physiological and pathological stimuli. In addition to several cytoplasmic substrates, calcineurin dephosphorylates members of the nuclear factor of activated T-cell (NFAT) family of transcription factors, resulting in their nuclear translocation and activation of target genes.
The is composed by two chains: chain A which is the catalytic subunit and the B chain confers calcium sensitivity.
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