Group:MUZIC:ZASP

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Z-disk alternatively spliced PDZ-motif (ZASP) protein

is a component protein of the striated muscle Z-disk and a member of the enigma family of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The structure of the N-terminal PDZ domain has been solved (PDB ID: 1RGW)

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. The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin [1] and myozenin, two other Z-disk members prominent during myofibrillogenesis and sarcomerogenesis.

doi: 10.1083/jcb.146.2.465 http://jcb.rupress.org/content/146/2/465.full

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Adekunle Onipe, Nikos Pinotsis, Michal Harel, Jaime Prilusky

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