Group:MUZIC:Titin

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Titin

Titin (also known as connectin or smitin) is the largest protein in human proteome. Is' size varies from 1,5 to approximately 4 MegaDaltons.


Complex of titin and telethonin

Drag the structure with the mouse to rotate

Z-disc portion of titin

portion of titin [1] [2] [3] [4] [5]



Function


Solved structures


Further reading:

  1. Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex. PMID 11573089
  2. Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. PMID 16407954
  3. The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin. PMID 16962974
  4. Third filament diseases.PMID 19181097
  5. The Z-disk diseases.PMID 19181098

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Victor Deineko

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