Group:MUZIC:ZASP

From Proteopedia

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Z-disk alternatively spliced PDZ-motif (ZASP) protein

is a component protein of the striated muscle Z-disk and a member of the enigma family of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The structure of the N-terminal PDZ domain has been solved (PDB ID: 1RGW)

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The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin [1] and myozenin, two other Z-disk members prominent during myofibrillogenesis and sarcomerogenesis http://proteopedia.org/wiki/index.php/User:Adekunle_Onipe/workbench/Sarcomerogenesis.

doi: 10.1083/jcb.146.2.465 http://jcb.rupress.org/content/146/2/465.full

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Function

Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the oracle of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin....