Group:MUZIC:Enigma Family
From Proteopedia
[1]==Enigma family: PDZ- and LIM-domain protein of the cytoskeleton== Three proteins have extensively been described and characterized within this subfamily: Enigma, Enigma Homologue (ENH) protein and ZASP/Cypher ('ZASP' being the human orthologue of 'Cypher' which is found in mouse and also identified by independent researchers who named it 'Oracle').
Didactically, protein members of the enigma subfamily typically possess within their structure: (1) an N-terminal PDZ domain (a domain which is named after the first three proteins where it was initially characterized i.e. PSD 95, Disc large protein and Zonula Occludens 1), and (2) three C-terminal LIM domain (a domain which is named after the first three proteins where it was characterized i.e. Lin-11, Isl1 and Mec-3) (1), (2).
The member proteins have all been located to the mammalian striated muscle, specifically in the heart and skeletal muscle Z-disk. They interact via their PDZ domains with motor protein components of the Z-disk and also recruit signalling molecules via thier LIM domain or internal motifs, for example ZM motif (ZASP-like motif which is sandwiched between the PDZ- and LIM-domains in ZASP).
These interactions via their PDZ- and LIM-domains have been suggested to be important for scaffolding interacting proteins in the sarcomere in order to maintain a proper architecture and physiologically functional muscle.
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Contents |
Enigma
Structure
Interactions within the Z-disk
Functions
Enigma Homologue (ENH)
Structure
Interaction within the Z-disk
Functions
ZASP/Cypher/Oracle
Structure
Interactions within the Z-disk
Functions
References
- ↑ Xia H, Winokur ST, Kuo WL, Altherr MR, Bredt DS. Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs. J Cell Biol. 1997 Oct 20;139(2):507-15. PMID:9334352
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