3oj8

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Image:3oj8.jpg

Template:STRUCTURE 3oj8

Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain

Template:ABSTRACT PUBMED 21428410

About this Structure

3oj8 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Reversible competitive alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. J Med Chem. 2011 Apr 28;54(8):2805-22. Epub 2011 Mar 23. PMID:21428410 doi:10.1021/jm101597x

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