2gx9

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Image:2gx9.gif

2gx9, resolution 2.100Å

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X-ray strucutre of influenza virus NS1 effector domain

Overview

The nonstructural protein NS1 of influenza virus is an antagonist of host, immune responses and is implicated in virulence. It has two domains, an, N-terminal double-stranded RNA-binding domain (RBD) and an effector domain, crucial for RBD function, for nuclear export and for sequestering, messenger RNA-processing proteins. Here we present the crystallographic, structure of the effector domain, which has a novel fold and suggests, mechanisms for increased virulence in H5N1 strains.

About this Structure

2GX9 is a Single protein structure of sequence from Unidentified influenza virus with as ligand. Full crystallographic information is available from OCA.

Reference

X-ray structure of influenza virus NS1 effector domain., Bornholdt ZA, Prasad BV, Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:16715094

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