Group:MUZIC:ALP
From Proteopedia
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ALP Subfamily: PDZ/LIM domain proteins of the cytoskeleton
On the basis of structural similarities, the ALP (α-Actinin-associated LIM domain Proteins) subfamily are related to the Enigma subfamily [1], containing PDZ/LIM-domains, as well as internal motifs viz ALP-like motif (AM) and ZASP-like motif (ZM). However, the ALP subfamily differs from the Enigma subfamily as each member of the ALP subfamily possess an N-terminal PDZ domain and only one C-terminal LIM domain.
Four proteins: ALP (aka PDLIM3)[1], CLP36[2] (aka hCLIM1(human)[3], Elfin (mouse)[4], PDLIM1), RIL[5] (aka PDLIM4) and Mystique[6],[7] (aka SLIM, PDLIM2) have been classified into the ALP subfamily.
CLP36 (C-terminal LIM Protein 36 kDa) and RIL (Reversion-Induced LIM) protein α-actinin-associated LIM protein (ALP) was first identified as a 39 kDa protein in rat skeletal muscle with a slightly shorter isoform in heart [8]. ALP includes both an N-terminal PDZ domain, which interacts with the a-actinin-2, and a C-terminal LIM domain. Thus, ALP shares a high degree of homology with previously characterized CLP-36 (Wang et al., 1995) and RIL (Kiess et al., 1995) proteins, suggesting a novel protein family containing an N-terminal PDZ domain and one C-terminal LIM motif (Xia et al., 1997).
Sequence annotation
Structure
Function and Interactions
Pathology
References
Proteopedia Page Contributors and Editors (what is this?)
Adekunle Onipe, Alexander Berchansky, Michal Harel, Nikos Pinotsis, Jaime Prilusky
