Group:MUZIC:XIN

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Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Intraexogic splicing leads to a least three different isoforms.

Contents

Sequence Annotation

Image:Xin.jpg


Interactions with other proteins/ Function

Xin and Mena/VASP colocalize with filamin c in [intercalated discs][1](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart [1].

Xin directly binds the EVH1 domain proteins Mena and VASP [2]

Proteopedia Page Contributors and Editors (what is this?)

Georg Mlynek, Nikos Pinotsis, Jaime Prilusky

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