Prolyl hydroxylase domain

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Prolyl hydroxylase domain (PHD) proteins mediate oxygen-dependent degradation of Hypoxia-inducible factor (HIF) α subunit. They include PHD1, PHD2 and PHD3. The PHD is a Fe+2/oxogluterate (2OG)-dependent enzyme. For more detalis see Molecular Playground/ Prolyl Hydroxylase Domain (PHD) Enzyme.