3rdp

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Template:STRUCTURE 3rdp

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT

Template:ABSTRACT PUBMED 21623543

About this Structure

3rdp is a 2 chain structure with sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

  • Martic M, Pernot L, Westermaier Y, Perozzo R, Kraljevic TG, Kristafor S, Raic-Malic S, Scapozza L, Ametamey S. Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids. 2011 Apr;30(4):293-315. PMID:21623543 doi:10.1080/15257770.2011.581258
  • Vogt J, Perozzo R, Pautsch A, Prota A, Schelling P, Pilger B, Folkers G, Scapozza L, Schulz GE. Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography. Proteins. 2000 Dec 1;41(4):545-53. PMID:11056041

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