Quinone reductase
From Proteopedia
Quinone reductase type 2 (QR2) catalyzes the reduction of adrenochrome. QR1 reduces quinines to the non-toxic hydroquinone. The sulfide-quinone reductase (SQR) reduces sulfide and thus provides electrons for phototropic processes in bacteria. NADPH-quinone reductase (NQR) catalyzes the reduction of quinone to semiquinone. The images at the left and at the right correspond to one representative Quinone reductase, i.e. the crystal structure of NADH quinone oxidoreductase (NQO1) with inhibitor dicoumarol (2f1o).
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3D Structures of Quinone reductase
Quinone reductase type 2
3fw1, 1qr2 – hQR2 - human
3o2n, 3g5m, 3gam – hQR2 + PET agent
3ovm, 3owh, 3owx – hQR2 + carbamate derivative
3ox1, 2qx4, 2qx6, 2qx8, 2qx9, 2qwx – hQR2 + acetamide derivative
3ox2 - hQR2 + indole derivative
3ox3 - hQR2 + carboxamide derivative
3o73 – hQR2 + indolequinone
2qmy – hQR2 + adrenochrome
2qr2 – hQR2 + menadione
2qmz – hQR2 + dopamine
1sg0 – hQR2 + resveratol
2bzs, 1xi2, 1zx1 – hQR2 + anti-cancer prodrug
Quinone reductase type 1
3jsx – hQR1 + coumarine derivative
2f1o – hQR1 + dicoumarol
1kbo, 1kbq – hQR1 + indole derivative
Sulfide-quinone reductase
3hyv – AaSQR – Aquifex aeolicus
3hyw – AaSQR + decylubiquinone
3hyx – AaSQR + Aurachin C
NADPH-quinone reductase
3ha2 – NQR – Pediococcus pentosaceus
1dxq, 1d4a - hNQR
1yb5 – hNQR + NADP
1gg5, 1h66, 1h69, 1qbg - hNQR + anti-cancer prodrug
1dxo - hNQR + quinone derivative
