2bcc

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spinqualitylabelsall models 2bcc, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

Overview

The cytochrome bc1 is one of the three major respiratory enzyme complexes, residing in the inner mitochondrial membrane. Cytochrome bc1 transfers, electrons from ubiquinol to cytochrome c and uses the energy thus released, to form an electrochemical gradient across the inner membrane. Our X-ray, crystal structures of the complex from chicken, cow and rabbit in both the, presence and absence of inhibitors of quinone oxidation, reveal two, different locations for the extrinsic domain of one component of the, enzyme, an iron-sulphur protein. One location is close enough to the, supposed quinol oxidation site to allow reduction of the Fe-S protein by, ubiquinol. The other site is close enough to cytochrome c1 to allow, oxidation of the Fe-S protein by the cytochrome. As neither location will, ... [(full description)]

About this Structure

2BCC is a [Single protein] structure of sequence from [Gallus gallus] with BOG, HEM, FES, U10, PEE and SIG as [ligands]. Active as [Ubiquinol--cytochrome-c reductase], with EC number [1.10.2.2]. Structure known Active Sites: BHI, BLO, C1H and FES. Full crystallographic information is available from [OCA].

Reference

Electron transfer by domain movement in cytochrome bc1., Zhang Z, Huang L, Shulmeister VM, Chi YI, Kim KK, Hung LW, Crofts AR, Berry EA, Kim SH, Nature. 1998 Apr 16;392(6677):677-84. PMID:9565029

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