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1h80
From Proteopedia
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1,3-ALPHA-1,4-BETA-D-GALACTOSE-4-SULFATE-3,6-ANHYDRO-D-GALACTOSE-2-SULFATE 4 GALACTOHYDROLASE
Overview
Carrageenans are gel-forming hydrocolloids extracted from the cell walls, of marine red algae. They consist of d-galactose residues bound by, alternate alpha(1-->3) and beta(1-->4) linkages and substituted by one, (kappa-carrageenan), two (iota-carrageenan), or three (lambda-carrageenan), sulfate-ester groups per disaccharide repeating unit. Both the kappa- and, iota-carrageenan chains adopt ordered conformations leading to the, formation of highly ordered aggregates of double-stranded helices. Several, kappa-carrageenases and iota-carrageenases have been cloned from marine, bacteria. Kappa-carrageenases belong to family 16 of the glycoside, hydrolases, which essentially encompasses polysaccharidases specialized in, the hydrolysis of the neutral polysaccharides such as agarose, ... [(full description)]
About this Structure
1H80 is a [Single protein] structure of sequence from [Alteromonas sp. atcc 43554] with CA, CL, NA and GOL as [ligands]. Active as [Iota-carrageenase], with EC number [3.2.1.157]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The iota-carrageenase of Alteromonas fortis. A beta-helix fold-containing enzyme for the degradation of a highly polyanionic polysaccharide., Michel G, Chantalat L, Fanchon E, Henrissat B, Kloareg B, Dideberg O, J Biol Chem. 2001 Oct 26;276(43):40202-9. Epub 2001 Aug 7. PMID:11493601
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